Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp. [see Adverse laboratory changes that were reported and occurring in greater than 0.2% of the patients were as follows: Hepatic: increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, lactate dehydrogenase (LDH), and bilirubin, Hematologic: increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased hematocrit, decreased white blood cell (WBC), shortened prothrombin time and shortened partial thromboplastin time, leukocytosis, hypokalemia, Renal: increased creatinine and increased blood urea nitrogen (BUN), Complicated Skin and Skin Structure Infections. The success rates for the clinically evaluable population are provided in Table 7. - Intravenous bolus injection (5 mL to 20 mL) is to be given over approximately 3 minutes to 5 minutes. Dosage and Administration (2.2), [see Meropenem is also used to treat bacterial meningitis (infection of brain or spinal cord). Table 6: Meropenem Pharmacokinetic Parameters in Patients Less Than 3 Months of Age Meropenem for injection is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 gram for intravenous administration, respectively. Staphylococcus epidermidis (MRSE). To email a medicine you must sign up and log in. As a precautionary measure, it is preferable to avoid the use of meropenem during pregnancy. A dose of up to 2 g three times daily in adults and adolescents and a dose of up to 40 mg/kg three times daily in children may be particularly appropriate when treating some types of infections, such as infections due to less susceptible bacterial species (e.g. Contents are Sterile. Staphylococcus aureus (methicillin-susceptible isolates only) Meropenem Injection 500MG Meropenem is used to treat severe infections of the skin or stomach. Clinical Pharmacology (12.3)]. Its empirical formula is C Date of first authorisation/renewal of the authorisation. Warnings and Precautions (5.4)]. Meropenem 500 mg: Each vial contains meropenem trihydrate equivalent to 500 mg anhydrous meropenem. Meropenem concentrations in the CSF of children with meningitis are approximately 20 % of concurrent plasma levels although there is significant inter-individual variability. Approximately 60 % of the dose is excreted in urine over 12 hours as meropenem with a further 12 % as metabolite. ), More about getting RSS News & Updates from DailyMed, Complicated skin and skin structure infections, 30 mL in 1 VIAL; Type 0: Not a Combination Product, 20 mL in 1 VIAL; Type 0: Not a Combination Product, 2 Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of There is no dose adjustment necessary (see section 4.2). Table 8: Clinical Efficacy Rates by Pathogen for Clinically Evaluable Population. See. The success rates in the clinically evaluable patients at the follow-up visit were 86% (225/261) in the meropenem arm and 83% (238/287) in imipenem-cilastatin arm. resistant to other antibiotics. As with other broad-spectrum antibacterial drugs, prolonged use of meropenem may result in overgrowth of nonsusceptible organisms. The pharmacokinetics of meropenem in neonates requiring anti-infective treatment showed greater clearance in neonates with higher chronological or gestational age with an overall average half-life of 2.9 hours. Pharmacokinetic studies performed in patients have not shown significant pharmacokinetic differences versus healthy subjects with equivalent renal function. Know Meropenem 500 MG Injection uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on Lybrate.com C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. Sodium content is 45.1 mg (1.96 mEq). However, bacteria may exhibit resistance to more than one class of antibacterials agents when the mechanism involved include impermeability and/or an efflux pump(s). Meropenem is hemodialyzable. Its structural formula is: Meropenem for injection is a white to pale yellow crystalline powder. <10 one-half unit dose every 24 hours Meropenem is cleared by haemodialysis. 2, intravenous meropenem was administered to dams from Gestation Day 17 until Lactation Day 21 at doses of 240, 500, and 1000 mg/kg/day. Know Meropenem 500 MG Injection uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on Lybrate.com Drug Interactions (7.1)]. The values represent the number of patients clinically cured/number of clinically evaluable patients at the post-treatment follow-up visit, with the percent cure in parentheses (Fully Evaluable analysis set). Skin and Subcutaneous Disorders: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme and acute generalized exanthematous pustulosis. Treatment of patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above. The dosage is based on your medical condition and response to treatment. The half-life is approximately one hour. Diminished renal function and central nervous system lesions may increase the risk of seizures. Clinical Pharmacology (12.3)]. A five minute intravenous bolus injection of meropenem in normal volunteers results in peak plasma levels of approximately 52 microgram/mL for the 500 mg dose and 112 microgram/mL for the 1 g dose. A study in patients with alcoholic cirrhosis shows no effect of liver disease on the pharmacokinetics of meropenem after repeated doses. Meropenem has been shown to be active against most isolates of the following microorganisms, both Use in Specific Populations (8.5),  The dose depends on what type of infection you have, where it … Meropenem does not have Treating physicians should refer to national and/or international consensus documents regarding the treatment of glanders and melioidosis. Adverse Reactions (6.1),  During therapy the patient's clinical status necessitated the addition of other antibacterial drugs.
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