Drug dosing in neonates should be based on integrated knowledge concerning the disease to be treated, the physiological characteristics of the neonate, and the pharmacokinetics (PK) and pharmacodynamics (PD) of a given drug. The dosing regimens in these simulations and NVP PK in preterm infants are being evaluated in the IMPAACT 1115 and 1106 trials. Monitoring Renal function – urea and electrolytes. Meropenem pharmacodynamic data from a mouse model of thigh infection. Distributions of steady state, intra‐dosage plasma meropenem concentrations in infants and children receiving currently recommended dosage regimens compared with target serum drug concentrations. Four hundred forty-six patients (397 pediatric patients 3 months to less than 17 years of age) were enrolled in 4 separate clinical trials and randomized to treatment with meropenem (n=225) at a dose of 40 mg/kg every 8 hours or a comparator drug, i.e., cefotaxime (n=187) or ceftriaxone (n=34), at the approved dosing regimens. To characterize meropenem single-dose and multiple-dose PK in subjects with suspected or complicated intra-abdominal infections. After an administration of 15 mg/kg meropenem twice-daily to premature infants, the mean total body clearance is 0.157 OBJECTIVE: To compare the clinical and microbiologic efficacy and safety of prolonged infusions versus conventional dosing of meropenem in neonates with Gram-negative late-onset sepsis (GN-LOS). In a study of 200 neonates and infants younger than 91 days of age with suspected or confirmed intra-abdominal infections, this dose was used in those patients younger than 32 weeks gestational age and at least 14 days post-natal age (n = 103). Multiple Dose Pharmacokinetic Study of Meropenem in Young Infants (<91 days) with Suspected or Complicated Intra-abdominal Infections Sponsor: NICHD Product Meropenem Objectives: a. It's FREE to register and you'll have access to drug information and much more. Europe PMC is an archive of life sciences journal literature. and the rest had fulminant sepsis. Necrotizing enterocolitis (NEC) continues to be a major cause of neonatal morbidity and mortality. We studied meropenem in 23 pre-term (gestational age, 29 to 36 weeks) and 15 full-term (gestational age, 37 to 42 weeks) neonates. Schmutzhard et al randomized 56 adults with bacterial meningitis to meropenem (n = 28), cefotaxime (n = 17) or ceftriaxone (n = 11). Except two, all cases responded well and survived. BACKGROUND: Hospitalized neonates are exposed to antibiotic-resistant bacterial pathogens and develop nosocomial infections. Oral dosing for chest infections in neonates without IV access (providing there have been no previous resistant gram negative bacteria isolated): dose as per BNFc (click icon to the left). Dose should be automatically adjusted by the pharmacist to 2g q8hr and modified to 500mg q6hr if the new culture yields an organism with a lower MIC. The dose of meropenem administered and the duration of treatment should take into account the type of infection to be treated, including its severity, and the clinical response. Guidelines & Resources WNHS Policy: Antimicrobial Stewardship Compatible Fluids November 2019; Clinical and Translational Science 13(2) DOI: 10.1111/cts.12710. Limited data are available regarding the neonatal pharmacokinetics of meropenem, a broad spectrum carbapenem antibiotic. Acinetobacter with a meropenem MIC of 4 mg/L. Mezlocillin & Piperacillin. Imipenem and meropenem have similar pharmacokinetic profile in children and show age associated changes[5]. Meropenem was studied in 200 neonates and infants less than 3 months of age. Meropenem was given over a variable period from 10-21 days at a dose of 20 mg/kg/dose 12th hourly for babies less than 7 days and 8 hourly for babies above 7 days old. Meropenem (Table 37–10) was approved by the FDA for use in children older than 3 months of age on the basis of extensive pediatric investigations across a wide range of infections, including meningitis and complicated abdominal infections [1, 494]. Podawać i.v. The dose of meropenem administered and the duration of treatment should take into account the type of infection to be treated, including its severity, and the clinical response. Listeria monocytogenes In vivo bactericidal activity of meropenem against Escherichia coli and Pseudomonas aeruginosa is plotted as a function of the percentage of the dosage interval that drug concentrations remained higher than the MIC for each organism. Search worldwide, life-sciences literature Dosing based on gestational age and serum creatinine (see Table: Vancomycin Dosage for Neonates) * The need to administer a test dose of amphotericin B is controversial. Use normal dose every 12 hours if estimated glomerular filtration rate 26–50 mL/minute/1.73 m 2.. Use half normal dose every 12 hours if estimated glomerular filtration rate 10–25 mL/minute/1.73 m 2.. Use half normal dose every 24 hours if estimated glomerular filtration rate less than 10 mL/minute/1.73 m 2. Each panel depicts one age/size group of subjects, as defined in Table 1. Meropenem. Mean half life of meropenem is1.7hrs in infants 2-5 months of age [5] and is about 1.5hrs up to 2yrs[3]. > 7 d: q 6-8 hr. Loading dose: 15 mg/kg IV. Dane dotyczące podania we wstrzyknięciu i.v. Objective: To compare the clinical and microbiologic efficacy and safety of prolonged infusions versus conventional dosing of meropenem in neonates with Gram-negative late-onset sepsis (GN-LOS). CFU, colony-forming units. Meropenem has not been sufficiently studied for safety and efficacy in neonates, and is not recommended unless an extended spectrum β lactamase producing organism is identified. Dosage Regimens for Meropenem in Children with Pseudomonas Infections Do Not Meet Serum Concentration Targets. u dzieci) można podawać we wstrzyknięciu i.v. Use normal dose every 12 hours if eGFR 26–50 mL/minute/1.73 m 2. Prescription drug information for thousands of brand, generic, and OTC medicines is available to registered members only.
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